Week 5 of the college football schedule is here and now it time to make our betting picks against the spread for the top games College football Week 5 picks, predictions against the spread ATS college football picks for Week 5 games Odds courtesy SI Sportsbook No. 7 Kentucky at No. 14 Ole Miss. The line is moving steadily in the Rebels favor despite UK getting elite rusher Chris Rodriguez back on the field. Ole Miss can run at will, on average more than 200 yards per game than Kentucky managed so far. Rodriguez can change that, but the Rebs have a defensive front presence that can clog those lanes, too. ATS pick: Ole Miss by 7, coversNo. 4 Michiganat Iowa. Say what you will about Iowa offense, and youd be right, but its defense is college football 6th best in total and is No. 1 allowing 5.8 points per game. That a real test for UM brilliant ground game and J.J. McCarthy big arm. Michigan has lost 4 of its last 5 at Iowa, which has defeated 5 out of its last 6 AP top 10 visitors. ATS pick: Michigan by 10, doesnt coverNo. 10 NC State at No. 5 Clemson. Another crucial division matchup for both teams as they come in undefeated. Clemson had the tougher test, fighting off Wake on the road despite a disastrous secondary performance. That could be an issue again going against Devin Leary, but Clemson has the front seven and a burgeoning downfield game to take and hold leads. ATS pick: Clemson by 6, doesnt coverRelated: College football scores | College football rankings | College football scheduleNo. 2 Alabamaat No. 20 Arkansas. The Hogs loss took some of the luster off this game, but not too much. Arkansas still has the protection and the ground attack to move the chains and maintain possession https://www.volunteersstore.com/Nico_Iamaleava_Jersey, but they havent faced the likes of the Tide physical scrimmage unit on defense, or the connection Bryce Young is building with his receivers. ATS pick: Alabama by 20, coversNo. 9 Oklahoma State at No. 16 Baylor. A rematch of the dramatic Big 12 title game with the Cowboys coming off an idle week. Blake Shapen is playing well for BU, but Spencer Sanders has looked great, leading college football 9th best passing attack and the 6th best scoring unit at almost 50 points per game. ATS pick: Oklahoma State by 5, upsetsNo. 1 Georgiaat Missouri. There will be talk about how close Georgia played Kent State, but there no reason to doubt what weve seen so far, a man-eating front seven and a cadre of skill players that can slip through just about any protection. But Mizzou may not have top receiver Luther Burden as he deals with an injury. ATS pick: Georgia by 23, doesnt coverArizona State at No. 6 USC. Caleb Williams and company pulled out an impressive close win at Oregon State and should be able to lean on the run against ASU poor ground defense. ATS pick: USC by 31, coversNo. 22 Wake Forest at No. 23 Florida State. Sam Hartman has the firepower to navigate the Seminoles back seven, but Wake has lost 5 straight at Doak, and FSU can run in tandem with Jordan Travis making plays at quarterback. ATS pick: Florida State by 5, doesnt coverOther ATS college football picksTexas Tech at No. 25 Kansas State. The Wildcats have taken the last 6 by an average of a TD per game and are coming off another win at OU. ATS pick: Kansas State by 6, doesnt coverNo. 18 Oklahomaat TCU. There one undefeated team on this field https://www.volunteersstore.com/Navy_Shuler_Jersey, and it not the Sooners, as the Horned Frogs are coming off a statement win over SMU. OU defense powers through here. ATS pick: Oklahoma by 8, coversPurdue at No. 21 Minnesota. Purdue might not have Aidan OConnell and struggled in a close win over FAU without him. The combo of Tanner Morgan and Mo Ibrahim is tough to stop for the 4-0 Gophers. ATS pick: Minnesota by 14, coversRutgers at No. 3 Ohio State. There no doubt OSU can out-gun anybody in the Big Ten James Pearce Jr. Jersey, but 40 points is a big line. ATS pick: Ohio State by 38, doesnt coverNorthwestern at No. 11 Penn State. Now that he has the tools, James Franklin wants to run the ball, which might bring down the point total. ATS pick: Penn State by 17, doesnt coverNo. 17 Texas AM at Mississippi State. What do the books know about the Bulldogs? AM is coming off a close win over Arkansas, is struggling mightily on offense, and just lost top receiver Ainias Smith.